Tang Guoqiang

as 张居正

Mei Ting

as 李贵妃

Feng Yuanzheng

as 冯保

Zhi Yitong

as 高拱

Wu Gang

as 朱载垕

Mei Nianjia

as 朱翊钧（大）

Zhao Jun

as 李延

Yang Xue

as 玉娘

Jian Wu