In Tokyo, a weak, unassertive boy named Sena Kobayakawa enters the high school of his choice, Deimon Private Senior High School. Sena's only remarkable physical abilities are his running speed and agility, which are noted by the school's American football team captain Yoichi Hiruma. Hiruma forces Sena to join the Deimon Devil Bats football team as its running back. To protect his identity from other teams who want to recruit him, Sena is forced to publicly assume the role of the team secretary and enter the field under the pseudonym of "Eyeshield 21" wearing a helmet with an eyeshield to hide his features.
as Sena Kobayakawa / Eyeshield 21 (voice)
as Yoichi Hiruma
as Mamori Anezaki
as Haruto Sakuraba
as Raimon Tarou
as Ryokan Kurita
as Hayato Akaba
as Kengo Mizumachi
as Devil Bat
as Niinobu Kasamatsu
as Naosumi Kadoguchi
as Osamu Kobanzame
as Atsushi Munakata
as Leonardo Apollo
as Rui Habashira
as Satoshi Muro
as Hormer Fitzgerald
as Koji Kuroki
as Suzuna
