The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines, and discovers a brilliant formula that reverses aging. But Sherman's thin and obnoxious alter ego, Buddy Love, wants out...and a big piece of the action. And when Buddy gets loose, things get seriously nutty.
as Sherman Klump / Buddy Love / Granny Klump / Mama Klump / Papa Klump / Young Papa Klump / Ernie Klump / Lance Perkins
as Denise
as Dean Richmond
as Jason
as Denise's Father
as Denise's Mother
as Leanne Guilford
as Ernie Klump, Jr.
as Issac
as Restaurant Manager
as Restaurant Trainee
as Dr. Knoll
as Bright Student
as Claudine
as Old Willie
as Chantal
as Stripper
as Preacher
as Bridesmaid
as Bridesmaid
as Party Guest / Bridesmaid
as Party Guest
as Mrs. Dudikoff
as Receptionist
as Man in Bathroom
as Man in Bathroom
as Zeke
as Baby Buddy
as Baby Buddy
as Baby Buddy
as Boardroom Member
as Boardroom Member
as Guy in Elevator
as Dancer
as Dancer
as Dancer
as Dancer
as Buddy at 15
as Sweet Old Lady with Dog
as Buxom Student
as Fraternity Student
as Lecture Student
as Heavyset Woman
as Krusty Reporter
as Cab Driver
as Four Star General
as Scientist
as Scientist
as Newscaster
as Scared Popcorn Man
as Scared Popcorn Man
as Scared Hot Dog Vendor
as Scared Little Girl
as Denise's Nosy Neighbor (uncredited)
